C₁₇H₁₇FN₄O₃

Base Information

• Chemical Name: C₁₇H₁₇FN₄O₃
• CAS No.: 1393605-19-0
• Molecular Formula: C₁₇H₁₇FN₄O₃
• Molecular Weight: 344.345
• Mol file: 1393605-19-0.mol

Synonyms:C₁₇H₁₇FN₄O₃

Chemical Property of C₁₇H₁₇FN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₇FN₄O₃

There total 4 articles about C₁₇H₁₇FN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-amino-5-iodo-7-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine (1393605-18-9) + phenylboronic acid (98-80-6) → C17H17FN4O3 (1393605-19-0)

Guidance literature:

With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.07.003

Reference yield:

((2R,3R,4S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate (98855-71-1) → C17H17FN4O3 (1393605-19-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Tris(3,6-dioxaheptyl)amine; potassium hydroxide / acetonitrile / 0.75 h / 20 °C

2: ammonium hydroxide; water / 1,4-dioxane / 16 h / 120 °C / Autoclave

3: sodium carbonate; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine / acetonitrile; water / 3 h / 80 °C / Inert atmosphere

With ammonium hydroxide; Tris(3,6-dioxaheptyl)amine; trisodium tris(3-sulfophenyl)phosphine; water; palladium diacetate; sodium carbonate; potassium hydroxide; In 1,4-dioxane; water; acetonitrile; 3: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.bmc.2012.07.003

Reference yield:

1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose (97614-43-2) → C17H17FN4O3 (1393605-19-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen bromide; acetic acid

2: Tris(3,6-dioxaheptyl)amine; potassium hydroxide / acetonitrile / 0.75 h / 20 °C

3: ammonium hydroxide; water / 1,4-dioxane / 16 h / 120 °C / Autoclave

4: sodium carbonate; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine / acetonitrile; water / 3 h / 80 °C / Inert atmosphere

With ammonium hydroxide; Tris(3,6-dioxaheptyl)amine; trisodium tris(3-sulfophenyl)phosphine; water; hydrogen bromide; palladium diacetate; sodium carbonate; acetic acid; potassium hydroxide; In 1,4-dioxane; water; acetonitrile; 4: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.bmc.2012.07.003

upstream raw materials:

4-amino-5-iodo-7-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

phenylboronic acid

((2R,3R,4S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate

1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose