1-allyl-4,6-dimethoxy-3-(4-methylphenyl)-7-(1-nitropent-4-en-2-yl)-1H-indole

Base Information

Chemical Name:1-allyl-4,6-dimethoxy-3-(4-methylphenyl)-7-(1-nitropent-4-en-2-yl)-1H-indole
CAS No.:1220960-58-6
Molecular Formula:C₂₅H₂₈N₂O₄
Molecular Weight:420.508
Hs Code.:

Synonyms:1-allyl-4,6-dimethoxy-3-(4-methylphenyl)-7-(1-nitropent-4-en-2-yl)-1H-indole

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Chemical Property of 1-allyl-4,6-dimethoxy-3-(4-methylphenyl)-7-(1-nitropent-4-en-2-yl)-1H-indole

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Technology Process of 1-allyl-4,6-dimethoxy-3-(4-methylphenyl)-7-(1-nitropent-4-en-2-yl)-1H-indole

There total 4 articles about 1-allyl-4,6-dimethoxy-3-(4-methylphenyl)-7-(1-nitropent-4-en-2-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1220960-54-2
1-allyl-3-(4-methylphenyl)-4,6-dimethoxy-7-(2-nitrovinyl)-1H-indole

: 1730-25-2
allylmagnesium bromide

: 1220960-58-6
1-allyl-4,6-dimethoxy-3-(4-methylphenyl)-7-(1-nitropent-4-en-2-yl)-1H-indole

Guidance literature:: 1-allyl-3-(4-methylphenyl)-4,6-dimethoxy-7-(2-nitrovinyl)-1H-indole; allylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran;
DOI:10.1016/j.tet.2011.04.019

Reference yield:

: 1220960-48-4
4,6-dimethoxy-3-(4-methylphenyl)-1H-indole-7-carbaldehyde

: 1220960-58-6
1-allyl-4,6-dimethoxy-3-(4-methylphenyl)-7-(1-nitropent-4-en-2-yl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / dimethyl sulfoxide / 1 h / 20 °C

2: ammonium acetate / isopropyl alcohol / 3 h / Reflux

3: tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

With ammonium acetate; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; isopropyl alcohol; 2: Henry reaction / 3: Michael addition;
DOI:10.1016/j.tet.2011.04.019

Reference yield:

: 956586-30-4
4,6-dimethoxy-3-(4-methylphenyl)-1H-indole

: 1220960-58-6
1-allyl-4,6-dimethoxy-3-(4-methylphenyl)-7-(1-nitropent-4-en-2-yl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 2.5 h / 20 °C

2: potassium hydroxide / dimethyl sulfoxide / 1 h / 20 °C

3: ammonium acetate / isopropyl alcohol / 3 h / Reflux

4: tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

With ammonium acetate; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; dimethyl sulfoxide; isopropyl alcohol; 3: Henry reaction / 4: Michael addition;
DOI:10.1016/j.tet.2011.04.019