ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)-5-nitrophenoxy)acetate

Base Information

• Chemical Name: ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)-5-nitrophenoxy)acetate
• CAS No.: 1459129-24-8
• Molecular Formula: C₁₉H₁₇NO₈
• Molecular Weight: 387.346
• Mol file: 1459129-24-8.mol

Synonyms:ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)-5-nitrophenoxy)acetate

Chemical Property of ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)-5-nitrophenoxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)-5-nitrophenoxy)acetate

There total 3 articles about ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)-5-nitrophenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl 2-(2-((4-methoxyphenyl)ethynyl)-5-nitrophenoxy)acetate (1459129-06-6) → ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)-5-nitrophenoxy)acetate (1459129-24-8)

Guidance literature:

With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate; magnesium sulfate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2013.07.104

Reference yield:

2-iodo-5-nitrophenol (197243-46-2) → ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)-5-nitrophenoxy)acetate (1459129-24-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 6 h / 20 °C / Reflux

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / Inert atmosphere; Reflux

3: sodium hydrogencarbonate; magnesium sulfate; sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 2 h / 20 °C

With ruthenium trichloride; sodium periodate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; magnesium sulfate; potassium carbonate; triethylamine; In tetrachloromethane; water; acetone; acetonitrile; 2: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tet.2013.07.104

Reference yield:

ethyl 2-(2-iodo-5-nitrophenoxy)acetate (1459128-88-1) → ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)-5-nitrophenoxy)acetate (1459129-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / Inert atmosphere; Reflux

2: sodium hydrogencarbonate; magnesium sulfate; sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 2 h / 20 °C

With ruthenium trichloride; sodium periodate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; magnesium sulfate; triethylamine; In tetrachloromethane; water; acetonitrile; 1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tet.2013.07.104

upstream raw materials:

2-iodo-5-nitrophenol

ethyl 2-(2-((4-methoxyphenyl)ethynyl)-5-nitrophenoxy)acetate

ethyl 2-(2-iodo-5-nitrophenoxy)acetate

Downstream raw materials:

6-nitrobenzofuran-2-carboxylic acid ethyl ester

4-methoxybenzoic acid