4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole

Base Information

Chemical Name:4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole
CAS No.:1027418-80-9
Molecular Formula:C₄₉H₄₁N₇
Molecular Weight:727.911
Hs Code.:

Synonyms:4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole

Suppliers and Price of 4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole

There total 6 articles about 4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4373-61-9
2-(m-tolyl)pyridine

: 1027418-80-9
4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 7 steps

1: 0.6 g / fuming HNO₃ / 0.5 h / -8 °C

2: H₂ / 10percent Pd/C

3: chlorobenzene / 100 °C

4: fuming HNO₃, 60percent H₂SO₄ / 0 °C

5: H₂ / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr

6: glacial CH₃COOH / 1.5 h / Heating

7: 1.) t-BuOK / 1.) DMF, 1 h, 2.) DMF, 14 h

With sulfuric acid; potassium tert-butylate; hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In methanol; chlorobenzene;
DOI:10.1021/jm00077a007

Reference yield:

: 1027890-78-3
2-Methyl-4-pyridin-2-yl-phenylamine

: 1027418-80-9
4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: chlorobenzene / 100 °C

2: fuming HNO₃, 60percent H₂SO₄ / 0 °C

3: H₂ / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr

4: glacial CH₃COOH / 1.5 h / Heating

5: 1.) t-BuOK / 1.) DMF, 1 h, 2.) DMF, 14 h

With sulfuric acid; potassium tert-butylate; hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In methanol; chlorobenzene;
DOI:10.1021/jm00077a007

Reference yield:

: 152628-07-4
2-(3-methyl-4-nitrophenyl)pyridine

: 1027418-80-9
4-Methyl-2-propyl-6-pyridin-2-yl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 10percent Pd/C

2: chlorobenzene / 100 °C

3: fuming HNO₃, 60percent H₂SO₄ / 0 °C

4: H₂ / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr

5: glacial CH₃COOH / 1.5 h / Heating

6: 1.) t-BuOK / 1.) DMF, 1 h, 2.) DMF, 14 h

With sulfuric acid; potassium tert-butylate; hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In methanol; chlorobenzene;
DOI:10.1021/jm00077a007