dimethyl trans-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,2-dihydronaphthalene-2,3-dicarboxylate

Base Information

Chemical Name:dimethyl trans-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,2-dihydronaphthalene-2,3-dicarboxylate
CAS No.:103531-49-3
Molecular Formula:C₂₄H₂₆O₈
Molecular Weight:442.466
Hs Code.:

Synonyms:dimethyl trans-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,2-dihydronaphthalene-2,3-dicarboxylate

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Chemical Property of dimethyl trans-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,2-dihydronaphthalene-2,3-dicarboxylate

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Technology Process of dimethyl trans-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,2-dihydronaphthalene-2,3-dicarboxylate

There total 12 articles about dimethyl trans-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,2-dihydronaphthalene-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 103477-65-2
(1S,2R,3S,4S)-1-(3,4-Dimethoxy-phenyl)-4,6,7-trimethoxy-1,2,3,4-tetrahydro-naphthalene-2,3-dicarboxylic acid dimethyl ester

: 103531-49-3
dimethyl trans-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,2-dihydronaphthalene-2,3-dicarboxylate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 16h; Heating;
DOI:10.1021/jo00368a018

Reference yield:

: C₂₄H₂₈O₉

: 103531-49-3
dimethyl trans-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,2-dihydronaphthalene-2,3-dicarboxylate

Guidance literature:: With hydrogenchloride; In water; at 0 - 5 ℃; for 36h; regioselective reaction;
DOI:10.1021/acs.orglett.0c02286

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 103531-49-3
dimethyl trans-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,2-dihydronaphthalene-2,3-dicarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / Br₂, CH₃COOH / 5 h / Ambient temperature

2: 98 percent / p-toluenosulfonic acid / benzene / 2 h / Heating

3: 1.) tetramethylene diamine, n-butyllithium, (n-Bu)3P*CuI / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, from -78 deg C to RT, 0.5 h

4: 95 percent / 10percent aq. HCl / diethyl ether / 2 h / Ambient temperature

5: 67 percent / SO₂ / thiophene / 8 h / Irradiation

6: p-toluenosulfonic acid / CH₂Cl₂ / 1 h / Heating

7: 82 percent / ZnO / benzene / 15 h / Heating

8: 99 percent / p-toluenosulfonic acid / toluene / 16 h / Heating

With hydrogenchloride; n-butyllithium; CuI*P(n-Bu)3; N,N,N,N,-tetramethylethylenediamine; sulfur dioxide; bromine; toluene-4-sulfonic acid; acetic acid; zinc(II) oxide; In thiophene; diethyl ether; dichloromethane; toluene; benzene;
DOI:10.1021/jo00368a018