2-methyl-5-phenyl-thiazole-4-carboxylic acid {(RS)-2-[(benzofuran-4-carbonyl)-amino]-1-cyclopropyl-ethyl}-methyl-amide

Base Information

Chemical Name:2-methyl-5-phenyl-thiazole-4-carboxylic acid {(RS)-2-[(benzofuran-4-carbonyl)-amino]-1-cyclopropyl-ethyl}-methyl-amide
CAS No.:1117693-63-6
Molecular Formula:C₂₆H₂₅N₃O₃S
Molecular Weight:459.569
Hs Code.:

Synonyms:2-methyl-5-phenyl-thiazole-4-carboxylic acid {(RS)-2-[(benzofuran-4-carbonyl)-amino]-1-cyclopropyl-ethyl}-methyl-amide

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Chemical Property of 2-methyl-5-phenyl-thiazole-4-carboxylic acid {(RS)-2-[(benzofuran-4-carbonyl)-amino]-1-cyclopropyl-ethyl}-methyl-amide

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Technology Process of 2-methyl-5-phenyl-thiazole-4-carboxylic acid {(RS)-2-[(benzofuran-4-carbonyl)-amino]-1-cyclopropyl-ethyl}-methyl-amide

There total 11 articles about 2-methyl-5-phenyl-thiazole-4-carboxylic acid {(RS)-2-[(benzofuran-4-carbonyl)-amino]-1-cyclopropyl-ethyl}-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1117693-67-0
(RS)-2-Cyclopropyl-2-[methyl-(2-methyl-5-phenyl-thiazole-4-carbonyl)-amino]-ethyl-ammonium chloride

: 166599-84-4
benzofuran-4-carboxylic acid

: 1117693-63-6
2-methyl-5-phenyl-thiazole-4-carboxylic acid {(RS)-2-[(benzofuran-4-carbonyl)-amino]-1-cyclopropyl-ethyl}-methyl-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 281191-38-6
cyclopropyl-(1-phenyl-ethylamino)-acetonitrile

: 1117693-63-6
2-methyl-5-phenyl-thiazole-4-carboxylic acid {(RS)-2-[(benzofuran-4-carbonyl)-amino]-1-cyclopropyl-ethyl}-methyl-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 4.17 h / 0 - 20 °C / Inert atmosphere

1.2: 0 °C

2.1: triethylamine / 66 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 90 h / 3750.38 Torr

4.1: water; methanol / 3 h

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

6.1: hydrogenchloride / 1,4-dioxane; methanol / 1.5 h

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1117693-59-0
1-cyclopropyl-N₁-(1-phenyl-ethyl)-ethane-1,2-diamine

: 1117693-63-6
2-methyl-5-phenyl-thiazole-4-carboxylic acid {(RS)-2-[(benzofuran-4-carbonyl)-amino]-1-cyclopropyl-ethyl}-methyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / 66 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 90 h / 3750.38 Torr

3: water; methanol / 3 h

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

5: hydrogenchloride / 1,4-dioxane; methanol / 1.5 h

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With hydrogenchloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;