(+)-(1R,cis)-3-[2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-ylaminomethyl]-2,2-dimethylcyclobutylmethanol

Base Information

Chemical Name:(+)-(1R,cis)-3-[2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-ylaminomethyl]-2,2-dimethylcyclobutylmethanol
CAS No.:247092-26-8
Molecular Formula:C₁₈H₂₂Cl₂N₆O
Molecular Weight:409.318
Hs Code.:

Synonyms:(+)-(1R,cis)-3-[2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-ylaminomethyl]-2,2-dimethylcyclobutylmethanol

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Chemical Property of (+)-(1R,cis)-3-[2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-ylaminomethyl]-2,2-dimethylcyclobutylmethanol

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Technology Process of (+)-(1R,cis)-3-[2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-ylaminomethyl]-2,2-dimethylcyclobutylmethanol

There total 2 articles about (+)-(1R,cis)-3-[2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-ylaminomethyl]-2,2-dimethylcyclobutylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 106-47-8
4-chloro-aniline

: 247092-25-7
(+)-(1R,cis)-3-(2-amino-6-chloropyrimidin-4-ylaminomethyl)-2,2-dimethylcyclobutylmethanol

: 247092-26-8
(+)-(1R,cis)-3-[2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-ylaminomethyl]-2,2-dimethylcyclobutylmethanol

Guidance literature:: With hydrogenchloride; sodium acetate; sodium nitrite; In acetic acid; at 20 ℃;
DOI:10.1248/cpb.47.1314

Reference yield:

: 171878-14-1
(1R,cis)-3-aminomethyl-2,2-dimethylcyclobutylmethanol

: 247092-26-8
(+)-(1R,cis)-3-[2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-ylaminomethyl]-2,2-dimethylcyclobutylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / Et₃N / butan-1-ol / 48 h / Heating

2: 87 percent / NaNO₂; 3 N aq. HCl; NaOAc*3H₂O / acetic acid / 20 °C

With hydrogenchloride; sodium acetate; triethylamine; sodium nitrite; In acetic acid; butan-1-ol; 1: Condensation / 2: Condensation;
DOI:10.1248/cpb.47.1314

Reference yield:

: 247092-26-8
(+)-(1R,cis)-3-[2-amino-6-chloro-5-(4-chlorophenylazo)pyrimidin-4-ylaminomethyl]-2,2-dimethylcyclobutylmethanol

: (-)-(1R,cis)-3-(5-amino-6,7-dihydro-7-oxo-3H-[1,2,3]tiazolo[4,5-d]pyrimidin-3-ylmethyl)-2,2-dimethylcyclobutylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / Zn; AcOH / H₂O; ethanol / 5 h / Heating

2: 85 percent / NaNO₂; HOAc / H₂O / 3 h

3: 70 percent / 0.25 N aq. NaOH / 5 h / Heating

With sodium hydroxide; acetic acid; zinc; sodium nitrite; In ethanol; water; 1: Reduction / 2: Condensation / 3: Hydrolysis;
DOI:10.1248/cpb.47.1314