(5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde

Base Information

Chemical Name:(5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde
CAS No.:1268265-27-5
Molecular Formula:C₁₉H₁₇NO₃
Molecular Weight:307.349
Hs Code.:

Synonyms:(5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde

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Chemical Property of (5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde

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Technology Process of (5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde

There total 17 articles about (5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₁₈INO₃

: 1268265-27-5
(5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃;
DOI:10.1038/ja.2014.14

Reference yield:

: 1268265-17-3
3-((1R,4S,5R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2,5-dimethylcyclopent-2-en-1-yl)-4-hydroxy-5-phenylpyridin-2(1H)-one

: 1268265-27-5
(5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodo-succinimide; pyridine / dichloromethane / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

3: pyridine; Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

With pyridine; N-iodo-succinimide; tetrabutyl ammonium fluoride; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1038/ja.2014.14

Reference yield:

: 1268265-26-4
(5aR,6R,7R,8R,8aS)-7-(hydroxymethyl)-6-iodo-5a,8-dimethyl-4-phenyl-2,5a,6,7,8,8a-hexahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridin-1-one

: 1268265-27-5
(5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

With pyridine; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; dimethyl sulfoxide;
DOI:10.1038/ja.2014.14