Toluene-4-sulfonic acid (R)-4-(4-benzyloxy-phenyl)-2-hydroxy-butyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid (R)-4-(4-benzyloxy-phenyl)-2-hydroxy-butyl ester
• CAS No.: 340825-62-9
• Molecular Formula: C₂₄H₂₆O₅S
• Molecular Weight: 426.533
• Mol file: 340825-62-9.mol

Synonyms:Toluene-4-sulfonic acid (R)-4-(4-benzyloxy-phenyl)-2-hydroxy-butyl ester

Chemical Property of Toluene-4-sulfonic acid (R)-4-(4-benzyloxy-phenyl)-2-hydroxy-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Toluene-4-sulfonic acid (R)-4-(4-benzyloxy-phenyl)-2-hydroxy-butyl ester

There total 1 articles about Toluene-4-sulfonic acid (R)-4-(4-benzyloxy-phenyl)-2-hydroxy-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(R)-glycidyl tosylate (113826-06-5,6746-81-2) + 4-(benzyloxy)benzylmagnesium chloride → Toluene-4-sulfonic acid (R)-4-(4-benzyloxy-phenyl)-2-hydroxy-butyl ester (340825-62-9)

Guidance literature:

With lithium chloride; copper dichloride; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0960-894X(00)00707-1

Reference yield: 86.0%

Toluene-4-sulfonic acid (R)-4-(4-benzyloxy-phenyl)-2-hydroxy-butyl ester (340825-62-9) → (R)-2-(4-benzyloxyphenethyl)oxirane (340825-63-0)

Guidance literature:

With potassium carbonate; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(00)00707-1

Reference yield:

Toluene-4-sulfonic acid (R)-4-(4-benzyloxy-phenyl)-2-hydroxy-butyl ester (340825-62-9) → 4-(4-{2-[2-(3,4-dimethoxy-phenyl)-1H-indol-3-yl]-ethylamino}-3-hydroxy-butyl)-phenol

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / K₂CO₃ / methanol; CH₂Cl₂

2: methanol / Heating

3: H₂ / Pd(OH)2

With hydrogen; potassium carbonate; palladium dihydroxide; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(00)00707-1

upstream raw materials:

(R)-glycidyl tosylate

Downstream raw materials:

(R)-2-(4-benzyloxyphenethyl)oxirane