tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate
CAS No.:1622205-31-5
Molecular Formula:C₃₃H₃₆FN₅O₆
Molecular Weight:617.677
Hs Code.:

Synonyms:tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Suppliers and Price of tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

There total 13 articles about tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 4-(4-(methoxycarbonyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1622205-31-5
tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 13 h / 20 °C

1.2: 0.75 h / 0 - 20 °C

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 1.05 h / -78 - 20 °C

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 3 h / 20 °C

4.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 3.17 h / 0 - 20 °C

With 1,2,3-Benzotriazole; thionyl chloride; dimethylsulfide borane complex; water; lithium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: tert-butyl 3-hydroxy-4-(4-(methoxycarbonyl)phenyl) piperidine-1-carboxylate

: 1622205-31-5
tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 1.05 h / -78 - 20 °C

2.1: lithium hydroxide; water / methanol; tetrahydrofuran / 3 h / 20 °C

3.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 3.17 h / 0 - 20 °C

With 1,2,3-Benzotriazole; thionyl chloride; water; lithium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1622205-30-4
tert-butyl 3-fluoro-4-(4-(methoxycarbonyl)phenyl)piperidine-1-carboxylate

: 1622205-31-5
tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / methanol; tetrahydrofuran / 3 h / 20 °C

2.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 3.17 h / 0 - 20 °C

With 1,2,3-Benzotriazole; thionyl chloride; water; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;