(R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester

Base Information

• Chemical Name: (R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester
• CAS No.: 937814-59-0
• Molecular Formula: C₁₈H₂₄ClNO₅
• Molecular Weight: 369.845
• Mol file: 937814-59-0.mol

Synonyms:(R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester

Chemical Property of (R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester

There total 3 articles about (R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (R)-2-pyrrolidone-5-carboxylate (68766-96-1) → (R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester (937814-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dmap / tetrahydrofuran / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 1 h / -40 °C

With triethylamine; dmap; In tetrahydrofuran;

Reference yield:

(4-chlorphenyl)magnesium bromide (873-77-8) + 1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate (144978-12-1,128811-48-3,144978-35-8,251924-83-1) → (R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester (937814-59-0)

Guidance literature:

(4-chlorphenyl)magnesium bromide; 1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate; In tetrahydrofuran; diethyl ether; at -40 - 0 ℃; for 1.33333h;

With water; at 0 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester (937814-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dmap / tetrahydrofuran / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 1 h / -40 °C

With triethylamine; dmap; In tetrahydrofuran;

upstream raw materials:

(4-chlorphenyl)magnesium bromide

1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate

di-tert-butyl dicarbonate

ethyl (R)-2-pyrrolidone-5-carboxylate

Downstream raw materials:

(2R,5S)-5-(4-chlorophenyl)pyrrolidine-2-carboxylic acid ethyl ester

(R)-5-(4-chlorophenyl)-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester

(S)-1-[(2R,5S)-5-(4-chlorophenyl)pyrrolidine-2-yl]ethanol

(2R,5S)-5-(4-chlorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester