2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one

Base Information

• Chemical Name: 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one
• CAS No.: 28754-28-1
• Molecular Formula: C21H19 N3 O3
• Molecular Weight: 361.4
• Mol file: 28754-28-1.mol

Synonyms:4(1H)-Quinazolinone,2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]- (9CI); C.I. 551210; C.I.Disperse Yellow 186; Disperse Yellow 186; Disperse Yellow S 10GL; SumikaronBrilliant Flavine S 10GL

Chemical Property of 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one

Chemical Property:

• Vapor Pressure: 0-0Pa at 20℃
• Boiling Point: 602.6°Cat760mmHg
• Flash Point: 318.2°C
• PSA: 79.20000
• Density: 1.3g/cm³
• LogP: 3.54270

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one

There total 4 articles about 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

isatoic anhydride (118-48-9) + 7-(diethylamino)-2-oxo-2H-chromene-3-carboximidamide → 2-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)quinazolin-4(1H)-one (28754-28-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201912027

Reference yield:

→ 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one (28754-28-1)

Guidance literature:

s.a. Bsp. 33, 61, 91;

Reference yield:

4-(Diethylamino)salicylaldehyde (17754-90-4) → 2-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)quinazolin-4(1H)-one (28754-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / ethanol / 0.42 h / 100 °C / Microwave irradiation; Sealed tube

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

With ammonium acetate; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/anie.201912027

upstream raw materials:

isatoic anhydride

4-(Diethylamino)salicylaldehyde