1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-4-iodobenzene

Base Information

Chemical Name:1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-4-iodobenzene
CAS No.:1453393-89-9
Molecular Formula:C₂₃H₂₃IN₄O₄
Molecular Weight:546.365
Hs Code.:

Synonyms:1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-4-iodobenzene

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Chemical Property of 1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-4-iodobenzene

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Technology Process of 1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-4-iodobenzene

There total 7 articles about 1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-4-iodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 335255-84-0
3-(3-Imidazol-1-yl-phenyl)-3-oxo-propionic Acid tert-butyl Ester

: 335255-25-9
2-amino-1-(tert-butoxycarbonylamino)-4-iodobenzene

: 1453393-89-9
1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-4-iodobenzene

Guidance literature:: In toluene; for 4h; Reflux;
DOI:10.1039/c3md00110e

Reference yield:

: 20691-72-9
4-iodo-2-nitroaniline

: 1453393-89-9
1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-4-iodobenzene

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; dmap / dichloromethane / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

3: tin(II) chloride dihdyrate / 3 h / 70 °C

4: toluene / 4 h / Reflux

With dmap; tin(II) chloride dihdyrate; triethylamine; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1039/c3md00110e

Reference yield:

: 4518-10-9
Methyl 3-aminobenzoate

: 1453393-89-9
1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-4-iodobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; methanol / 18 h / 20 °C

1.2: 1 h / Reflux

1.3: 5 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

3.1: toluene / 4 h / Reflux

With lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; toluene; 2.1: |Claisen Condensation;
DOI:10.1039/c3md00110e