2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-benzimidazole

Base Information

Chemical Name:2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-benzimidazole
CAS No.:855959-49-8
Molecular Formula:C₂₉H₂₆N₂O
Molecular Weight:418.538
Hs Code.:

Synonyms:2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-benzimidazole

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Chemical Property of 2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-benzimidazole

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Technology Process of 2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-benzimidazole

There total 7 articles about 2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 855959-40-9
(2R)-N-(2-aminophenyl)-3-(benzyloxy)-2-([1,1'-biphenyl-4-yl]methyl)propanamide

: 855959-49-8
2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-benzimidazole

Guidance literature:: With acetic acid; at 65 ℃; for 2.5h;
DOI:10.1002/hlca.200590051

Reference yield:

: 855959-36-3
(2R)-3-(benzyloxy)-2-([1,1'-biphenyl-4-yl]methyl)propanoic acid

: 855959-49-8
2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: (COCl)2 / CH₂Cl₂ / 12 h / 20 °C

1.2: 66 percent / NEt₃ / tetrahydrofuran / 12 h / 20 °C

2.1: 85 percent / AcOH / 2.5 h / 65 °C

With oxalyl dichloride; acetic acid; In dichloromethane;
DOI:10.1002/hlca.200590051

Reference yield:

: 855959-31-8
(4S)-4-benzyl-3-[(2R)-3-(benzyloxy)-2-([1,1'-biphenyl-4-yl]methyl)propanoyl]-1,3-oxazolidin-2-one

: 855959-49-8
2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 73 percent / H₂O₂; LiOH*H₂O / tetrahydrofuran; H₂O / 2.5 h / 20 °C

2.1: (COCl)2 / CH₂Cl₂ / 12 h / 20 °C

2.2: 66 percent / NEt₃ / tetrahydrofuran / 12 h / 20 °C

3.1: 85 percent / AcOH / 2.5 h / 65 °C

With lithium hydroxide; oxalyl dichloride; dihydrogen peroxide; acetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/hlca.200590051