9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-chloro-6-(4,5-diphenylimidazol-1-yl)purine

Base Information

• Chemical Name: 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-chloro-6-(4,5-diphenylimidazol-1-yl)purine
• CAS No.: 891497-95-3
• Molecular Formula: C₃₁H₂₇ClN₆O₇
• Molecular Weight: 631.044

Synonyms:9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-chloro-6-(4,5-diphenylimidazol-1-yl)purine

Chemical Property of 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-chloro-6-(4,5-diphenylimidazol-1-yl)purine

Chemical Property:

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Technology Process of 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-chloro-6-(4,5-diphenylimidazol-1-yl)purine

There total 2 articles about 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-chloro-6-(4,5-diphenylimidazol-1-yl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(2R,3R,4R,5R)-4-(acetyloxy)-2-[(acetyloxy)methyl]-5-(2,6-dichloro-9H-purin-9-yl)tetrahydro-3-furanyl acetate (3056-18-6) + 4,5-diphenyl-1H-imidazole (668-94-0) → 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-chloro-6-(4,5-diphenylimidazol-1-yl)purine (891497-95-3)

Guidance literature:

In N,N-dimethyl-formamide; at 65 ℃; for 67h;

Reference yield: 81.0%

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-amino-6-(4,5-diphenyl-imidazol-1-yl)-purin-9-yl]-tetrahydro-furan-3-yl ester → 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-chloro-6-(4,5-diphenylimidazol-1-yl)purine (891497-95-3)

Guidance literature:

With chloro-trimethyl-silane; benzyltriethylammonium nitrite; In dichloromethane;

DOI:10.1021/jo060340o

Reference yield: 67.0%

9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-chloro-6-(4,5-diphenylimidazol-1-yl)purine (891497-95-3) → 2-chloro-6-(4,5-diphenylimidazol-1-yl)purine (891497-96-4)

Guidance literature:

With acetic acid; acetyl chloride; at 65 ℃; for 60h;

upstream raw materials:

(2R,3R,4R,5R)-4-(acetyloxy)-2-[(acetyloxy)methyl]-5-(2,6-dichloro-9H-purin-9-yl)tetrahydro-3-furanyl acetate

4,5-diphenyl-1H-imidazole

Downstream raw materials:

2-chloro-6-(4,5-diphenylimidazol-1-yl)purine

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