(1R,2S,3R,5S)-(p-fluorophenyl)-2-(3'-methyl-1',2',4-oxadiazol-5'-yl)tropane

Base Information

• Chemical Name: (1R,2S,3R,5S)-(p-fluorophenyl)-2-(3'-methyl-1',2',4-oxadiazol-5'-yl)tropane
• CAS No.: 168254-92-0
• Molecular Formula: C₁₇H₂₀FN₃O
• Molecular Weight: 301.364
• Mol file: 168254-92-0.mol

Synonyms:(1R,2S,3R,5S)-(p-fluorophenyl)-2-(3'-methyl-1',2',4-oxadiazol-5'-yl)tropane

Chemical Property of (1R,2S,3R,5S)-(p-fluorophenyl)-2-(3'-methyl-1',2',4-oxadiazol-5'-yl)tropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,3R,5S)-(p-fluorophenyl)-2-(3'-methyl-1',2',4-oxadiazol-5'-yl)tropane

There total 1 articles about (1R,2S,3R,5S)-(p-fluorophenyl)-2-(3'-methyl-1',2',4-oxadiazol-5'-yl)tropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(4-fluorophenyl)lithium (1493-23-8) + (1R,5S)-2-(3'-methyl-1',2',4'-oxadiazol-5'-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene → (1R,2S,3R,5S)-(p-fluorophenyl)-2-(3'-methyl-1',2',4-oxadiazol-5'-yl)tropane (168254-92-0)

Guidance literature:

(4-fluorophenyl)lithium; In tetrahydrofuran; pentane; at -78 ℃; for 2h;

(1R,5S)-2-(3'-methyl-1',2',4'-oxadiazol-5'-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene;

Reference yield:

(1R,2S,3R,5S)-(p-fluorophenyl)-2-(3'-methyl-1',2',4-oxadiazol-5'-yl)tropane (168254-92-0) → (1R)-N-methyl-2β-methoxycarbonyl-3α-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane (157008-48-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; diethyl ether;

DOI:10.1016/0040-4039(95)00477-T

upstream raw materials:

(4-fluorophenyl)lithium

Downstream raw materials:

(1R)-N-methyl-2β-methoxycarbonyl-3α-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane