20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate

Base Information

Chemical Name:20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate
CAS No.:150187-25-0
Molecular Formula:C₃₅H₅₀O₆S
Molecular Weight:598.844
Hs Code.:

Synonyms:20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate

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Chemical Property of 20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate

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Technology Process of 20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate

There total 8 articles about 20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 98-59-9
p-toluenesulfonyl chloride

: 150187-24-9
3β-hydroxy-20-oxo-5α-pregnane-11α-yl cyclohexanecarboxylate

: 150187-25-0
20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate

Guidance literature:: With pyridine; for 18h; Ambient temperature;
DOI:10.1135/cccc19930619

Reference yield:

: 150187-20-5
20,20-ethylenedioxy-3β-hydroxy-5-pregnen-11α-yl benzoate

: 150187-25-0
20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 18 h / Ambient temperature

2: 72percent perchloric acid / acetone

3: 1.) H₂, 2.) K₂CO₃ / 1.) Adams platinum catalyst / 1.) acetic acid, 5 h, 2.) methanol, water, 0 deg C, 64 h

4: 87 percent / pyridine / 18 h / Ambient temperature

With pyridine; perchloric acid; hydrogen; potassium carbonate; platinum(IV) oxide; In acetone;
DOI:10.1135/cccc19930619

Reference yield:

: 104396-80-7
11α-benzoyloxyprogesterone

: 150187-25-0
20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / 72percent perchloric acid / ethyl acetate / 0.5 h

2: 94 percent / p-toluenesulfonic acid monohydrate / benzene / 6 h / Heating

3: 83 percent / NaBH₄ / ethanol / 2 h

4: pyridine / 18 h / Ambient temperature

5: 72percent perchloric acid / acetone

6: 1.) H₂, 2.) K₂CO₃ / 1.) Adams platinum catalyst / 1.) acetic acid, 5 h, 2.) methanol, water, 0 deg C, 64 h

7: 87 percent / pyridine / 18 h / Ambient temperature

With pyridine; sodium tetrahydroborate; perchloric acid; hydrogen; potassium carbonate; toluene-4-sulfonic acid; platinum(IV) oxide; In ethanol; ethyl acetate; acetone; benzene;
DOI:10.1135/cccc19930619