ethyl (R)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

Base Information

Chemical Name:ethyl (R)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate
CAS No.:1322081-09-3
Molecular Formula:C₁₅H₁₅ClO₄
Molecular Weight:294.735
Hs Code.:

Synonyms:ethyl (R)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

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Chemical Property of ethyl (R)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

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Technology Process of ethyl (R)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

There total 3 articles about ethyl (R)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1075-77-0
4-chlorocinnamaldehyde

: 141-97-9
ethyl acetoacetate

: 1322081-09-3
ethyl (R)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

Guidance literature:: With 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; C₂₁H₂₂N₃O⁽¹⁺⁾*Cl^(1-); In toluene; at 40 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1039/c1cc12778k

Reference yield: 49.0%

: 67228-76-6
4-chlorophenylpropynal

: 141-97-9
ethyl acetoacetate

: 1322081-09-3
ethyl (R)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

Guidance literature:: With C₂₁H₂₂N₃O⁽¹⁺⁾*Cl^(1-); In toluene; at 40 ℃; for 8h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1039/c1cc12778k

Reference yield:

: 4-nitrophenyl 3-(4-chlorophenyl)propanoate

: 141-97-9
ethyl acetoacetate

: 1322081-09-3
ethyl (R)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

: (S)-ethyl 4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyran-5-carboxylate

Guidance literature:: With (5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; potassium acetate; benzotriazol-1-ol; lithium chloride; In tetrahydrofuran; at 35 ℃; for 36h; Overall yield = 73 %; Overall yield = 21.5 mg; enantioselective reaction; Schlenk technique; Inert atmosphere; Molecular sieve; Sealed tube;
DOI:10.1021/acs.orglett.7b03650