4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester

Base Information

Chemical Name:4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester
CAS No.:868707-56-6
Molecular Formula:C₂₆H₃₁N₅O₇
Molecular Weight:525.561
Hs Code.:

4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester

Synonyms:4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester

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Chemical Property of 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester

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Technology Process of 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester

There total 8 articles about 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 291509-61-0
3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

: 868707-55-5
(R)-3-(4-amino-3-methyl-5-nitro-phenyl)-2-hydroxy-propionic acid methyl ester

: 868707-56-6
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester

Guidance literature:: 4-Nitrophenyl chloroformate; With pyridine; dmap; at 0 - 20 ℃; for 0.5h;

3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one; (R)-3-(4-amino-3-methyl-5-nitro-phenyl)-2-hydroxy-propionic acid methyl ester; at 20 ℃; for 7h;

Reference yield: 50.0%

: 291509-61-0
3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

: 868707-56-6
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester

Guidance literature:: 4-Nitrophenyl chloroformate; With pyridine; dmap; at 0 - 20 ℃; for 0.5h;

(R)-3-(4-amino-3-methyl-5-nitro-phenyl)-2-hydroxy-propionic acid methyl ester; at 20 ℃; for 2h;

3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one; at 20 ℃; for 5h;

Reference yield:

: 77811-44-0
4-bromo-2-methyl-6-nitroaniline

: 868707-56-6
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-methoxycarbonyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 24 h / 90 °C

2.1: hydrogenchloride; water / 1,4-dioxane / 3 h / Heating / reflux

3.1: (1R)-B-chloro-diisopinocampheylborane; triethylamine / tetrahydrofuran / -35 - 20 °C

3.2: 0.25 h / 5 °C

3.3: 0 °C

4.1: thionyl chloride / 2 h / 0 - 20 °C / Cooling with acetone/ice

5.1: pyridine; dmap / 0.5 h / 0 - 20 °C

5.2: 2 h / 20 °C

6.1: 5 h / 20 °C

With pyridine; hydrogenchloride; dmap; thionyl chloride; (1R)-B-chloro-diisopinocampheylborane; water; triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; 1,4-dioxane; acetonitrile;