3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile

Base Information

Chemical Name:3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile
CAS No.:1266519-66-7
Molecular Formula:C₂₀H₁₁ClF₂N₄O₂S
Molecular Weight:444.849
Hs Code.:

Synonyms:3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile

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Chemical Property of 3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile

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Technology Process of 3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile

There total 6 articles about 3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1266520-02-8
1-{[5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

: (3-cyano-5-fluorophenyl)boronic acid

: 1266519-66-7
3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 1266519-66-7
3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane; dimethyl sulfoxide / 90 °C / Inert atmosphere

2: sodium periodate; ammonium acetate / water; acetone / 20 °C

3: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

With sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; potassium acetate; sodium hydrogencarbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide; acetone;

Reference yield:

: 1266519-92-9
ethyl 4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate

: 1266519-66-7
3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; iron(III) chloride / dichloromethane / 18 h / Reflux

2: lithium hydroxide; water / tetrahydrofuran / 20 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / 20 °C

4: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

With iron(III) chloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;