Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester

Base Information

• Chemical Name: Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester
• CAS No.: 190711-63-8
• Molecular Formula: C₂₀H₁₇F₃N₂O₂S
• Molecular Weight: 406.428
• Mol file: 190711-63-8.mol

Synonyms:Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester

Chemical Property of Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester

There total 1 articles about Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetic anhydride (108-24-7) + 1-(4-Methanesulfinyl-phenyl)-5-p-tolyl-3-trifluoromethyl-1H-pyrazole (190711-47-8) → Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester (190711-63-8)

Guidance literature:

With sodium acetate; for 2h; Heating;

DOI:10.1055/s-1997-801

Reference yield:

Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester (190711-63-8) → 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide (169590-42-5,194044-54-7)

Guidance literature:

Multi-step reaction with 4 steps

1: magnesium monoperoxyphthalate / methanol; CH₂Cl₂

2: 100 percent / 1N NaOH / methanol; tetrahydrofuran / 1 h / 0 °C

3: SO₂Cl₂ / CH₂Cl₂ / -5 °C

4: aq. ammonium hydroxide

With ammonium hydroxide; sodium hydroxide; sulfuryl dichloride; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1055/s-1997-801

Reference yield:

Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester (190711-63-8) → Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonylmethyl ester (190711-64-9)

Guidance literature:

With magnesium monoperoxyphthalate hexahydrate; In methanol; dichloromethane; Yield given;

DOI:10.1055/s-1997-801

upstream raw materials:

acetic anhydride

1-(4-Methanesulfinyl-phenyl)-5-p-tolyl-3-trifluoromethyl-1H-pyrazole

Downstream raw materials:

Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonylmethyl ester

4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide

4-[5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonyl chloride

Refernces