Carbamic acid, (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester

Base Information

Chemical Name:Carbamic acid, (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS No.:82585-98-6
Molecular Formula:C₁₆H₁₅Cl₂N₅O₂
Molecular Weight:380.233
Hs Code.:
DSSTox Substance ID:DTXSID40231896
Wikidata:Q83112891
ChEMBL ID:CHEMBL9517

Synonyms:82585-98-6;Carbamic acid, (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester;CHEMBL9517;DTXSID40231896;Ethyl (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate;ethyl N-[5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate;N-[5-Amino-3-(3,4-dichlorophenyl)(1,2-dihydropyridino[5,4-b]pyrazin-7-yl)]ethoxycarboxamide

Suppliers and Price of Carbamic acid, (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester

Chemical Property:

Vapor Pressure:2.43E-11mmHg at 25°C
XLogP3:3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:379.0602801
Heavy Atom Count:25
Complexity:521

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)NC1=NC(=C2C(=C1)NCC(=N2)C3=CC(=C(C=C3)Cl)Cl)N

Technology Process of Carbamic acid, (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester

There total 5 articles about Carbamic acid, (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 82585-79-3
{6-Amino-4-[2-(3,4-dichloro-phenyl)-2-oxo-ethylamino]-5-nitro-pyridin-2-yl}-carbamic acid ethyl ester

: 82585-98-6
[5-Amino-3-(3,4-dichloro-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester

Guidance literature:: With hydrogen; nickel; In 1,4-dioxane; ethanol; for 40h; under 760 Torr; Heating;
DOI:10.1021/jm00351a008

Reference yield:

: 6506-86-1
ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate

: 82585-98-6
[5-Amino-3-(3,4-dichloro-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / Et₃N / ethanol / 1.5 h / 75 °C

2: 69 percent / 1N aq. HCl / dioxane / 6 h / 60 °C

3: 57 percent / H₂ / Raney nickel / ethanol; dioxane / 40 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; triethylamine; nickel; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00351a008

Reference yield:

: 82585-37-3
2-Amino-1-(3,4-dichloro-phenyl)-ethanone oxime

: 82585-98-6
[5-Amino-3-(3,4-dichloro-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / Et₃N / ethanol / 1.5 h / 75 °C

2: 69 percent / 1N aq. HCl / dioxane / 6 h / 60 °C

3: 57 percent / H₂ / Raney nickel / ethanol; dioxane / 40 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; triethylamine; nickel; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00351a008