5-(tert-butyldiphenylsilanyloxy)-4-dibenzylamino-3-phenylpentanoic acid methyl ester

Base Information

Chemical Name:5-(tert-butyldiphenylsilanyloxy)-4-dibenzylamino-3-phenylpentanoic acid methyl ester
CAS No.:927682-96-0
Molecular Formula:C₄₂H₄₇NO₃Si
Molecular Weight:641.926
Hs Code.:

Synonyms:5-(tert-butyldiphenylsilanyloxy)-4-dibenzylamino-3-phenylpentanoic acid methyl ester

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Chemical Property of 5-(tert-butyldiphenylsilanyloxy)-4-dibenzylamino-3-phenylpentanoic acid methyl ester

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Technology Process of 5-(tert-butyldiphenylsilanyloxy)-4-dibenzylamino-3-phenylpentanoic acid methyl ester

There total 2 articles about 5-(tert-butyldiphenylsilanyloxy)-4-dibenzylamino-3-phenylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 927682-95-9
5-(tert-butyldiphenylsilanyloxy)-4-dibenzylaminopent-2-enoic acid methyl ester

: 108-86-1,52753-63-6
bromobenzene

: 927682-96-0
5-(tert-butyldiphenylsilanyloxy)-4-dibenzylamino-3-phenylpentanoic acid methyl ester

Guidance literature:: bromobenzene; With magnesium; In tetrahydrofuran;

With copper(l) iodide; In tetrahydrofuran; at -78 ℃; for 0.666667h;

5-(tert-butyldiphenylsilanyloxy)-4-dibenzylaminopent-2-enoic acid methyl ester; With chloro-trimethyl-silane; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.tetasy.2006.11.029

Reference yield:

: 800391-47-3
3-(tert-butyldiphenylsilanyloxy)-2-dibenzylamino-1-propanol

: 927682-96-0
5-(tert-butyldiphenylsilanyloxy)-4-dibenzylamino-3-phenylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.33 h / -78 °C

1.2: 90.6 percent / CH₂Cl₂ / 16 h / -78 - 20 °C

2.1: Mg / tetrahydrofuran

2.2: CuI / tetrahydrofuran / 0.67 h / -78 °C

2.3: 58 percent / Me₃SiCl / tetrahydrofuran / -78 - 20 °C

With oxalyl dichloride; magnesium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation / 1.2: Wittig olefination;
DOI:10.1016/j.tetasy.2006.11.029