1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone

Base Information

Chemical Name:1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone
CAS No.:1451998-91-6
Molecular Formula:C₂₂H₂₆O₅
Molecular Weight:370.445
Hs Code.:

Synonyms:1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone

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Chemical Property of 1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone

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Technology Process of 1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone

There total 8 articles about 1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₄N₂O₅

: 1451998-91-6
1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone

Guidance literature:: With copper(ll) sulfate pentahydrate; water; In methanol; at 60 ℃; for 1.5h;
DOI:10.1002/ejoc.201300097

Reference yield:

: 726193-05-1
(4S)-1-bromo-4,5-cyclohexylidenedioxypentane

: 1451998-91-6
1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: copper(ll) sulfate pentahydrate; water / methanol / 1.5 h / 60 °C

3.1: sodium tetrahydroborate / methanol / 1 h

4.1: toluene-4-sulfonic acid; methanol / 15 h / Inert atmosphere

5.1: carbon tetrabromide; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

6.2: 2 h / 20 °C

7.1: copper(ll) sulfate pentahydrate; water / methanol / 1.5 h / 60 °C

With methanol; sodium tetrahydroborate; copper(ll) sulfate pentahydrate; carbon tetrabromide; water; sodium hydride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300097

Reference yield:

: 1451998-74-5
(S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-one

: 1451998-91-6
1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 1 h

2.1: toluene-4-sulfonic acid; methanol / 15 h / Inert atmosphere

3.1: carbon tetrabromide; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

4.2: 2 h / 20 °C

5.1: copper(ll) sulfate pentahydrate; water / methanol / 1.5 h / 60 °C

With methanol; sodium tetrahydroborate; copper(ll) sulfate pentahydrate; carbon tetrabromide; water; sodium hydride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300097