(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanoxy)-3-(furan-2-yl)propionaldehyde

Base Information

Chemical Name:(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanoxy)-3-(furan-2-yl)propionaldehyde
CAS No.:768392-18-3
Molecular Formula:C₂₀H₂₈O₄Si
Molecular Weight:360.525
Hs Code.:

Synonyms:(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanoxy)-3-(furan-2-yl)propionaldehyde

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Chemical Property of (2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanoxy)-3-(furan-2-yl)propionaldehyde

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Technology Process of (2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanoxy)-3-(furan-2-yl)propionaldehyde

There total 6 articles about (2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanoxy)-3-(furan-2-yl)propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 768392-12-7
(S)-4-Benzyl-3-[(1S,2S,3S)-2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3-furan-2-yl-1-hydroxy-propyl]-5,5-dimethyl-oxazolidin-2-one

: 768392-18-3
(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanoxy)-3-(furan-2-yl)propionaldehyde

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 0.25h;
DOI:10.1016/j.tet.2004.05.123

Reference yield:

: 98-01-1
furfural

: 768392-18-3
(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanoxy)-3-(furan-2-yl)propionaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / CF₃SO₃H; (i-Pr)2NEt; Et₃B / CH₂Cl₂; hexane / 1.5 h / -78 - 0 °C

2: 88 percent / imidazole; DMAP / dimethylformamide / 18 h / 20 °C

3: 90 percent / DIBAL / CH₂Cl₂ / 0.33 h / -78 °C

4: 85 percent / aq. K₂CO₃ / methanol / 0.25 h / 20 °C

With 1H-imidazole; dmap; triethyl borane; trifluorormethanesulfonic acid; diisobutylaluminium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.05.123

Reference yield:

: 19810-31-2
Benzyloxyacetyl chloride

: 768392-18-3
(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanoxy)-3-(furan-2-yl)propionaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / n-BuLi / tetrahydrofuran / 2.25 h / -78 - 20 °C

2: 81 percent / CF₃SO₃H; (i-Pr)2NEt; Et₃B / CH₂Cl₂; hexane / 1.5 h / -78 - 0 °C

3: 88 percent / imidazole; DMAP / dimethylformamide / 18 h / 20 °C

4: 90 percent / DIBAL / CH₂Cl₂ / 0.33 h / -78 °C

5: 85 percent / aq. K₂CO₃ / methanol / 0.25 h / 20 °C

With 1H-imidazole; dmap; n-butyllithium; triethyl borane; trifluorormethanesulfonic acid; diisobutylaluminium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.05.123