(1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:(1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester
CAS No.:309761-66-8
Molecular Formula:C₂₆H₃₈O₈
Molecular Weight:478.583
Hs Code.:

Synonyms:(1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Suppliers and Price of (1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

There total 1 articles about (1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 93836-48-7
(S)-2-(trifluoromethanesulphonyloxy)propionic acid benzyl ester

: 221344-09-8
(1S,2S,4R,5S)-4,5-Dihydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

: 309761-66-8
(1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: (1S,2S,4R,5S)-4,5-Dihydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester; With di(n-butyl)tin oxide; In benzene; Heating;

(S)-2-(trifluoromethanesulphonyloxy)propionic acid benzyl ester; With tetra-(n-butyl)ammonium iodide; In benzene;
DOI:10.1016/S0960-894X(00)00428-5

Reference yield: 38.0%

: 309761-66-8
(1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

: Trichloro-acetic acid (3R,4R,5R,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl ester

: 309761-70-4
4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-benzyloxycarbonyl-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; Heating;
DOI:10.1016/S0960-894X(00)00428-5

Reference yield:

: 309761-66-8
(1S,2S,4R,5S)-4-((S)-1-Benzyloxycarbonyl-ethoxy)-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

: 4-[3-acetylamino-5-hydroxy-6-hydroxymethyl-4-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 38 percent / TMSOTf / CH₂Cl₂ / Heating

2: 90 percent / H₂ / Pd/C

3: 85 percent / MeONa; MeOH

With methanol; trimethylsilyl trifluoromethanesulfonate; hydrogen; sodium methylate; palladium on activated charcoal; In dichloromethane; 1: glycosylation / 2: Hydrogenolysis / 3: methanolysis;
DOI:10.1016/S0960-894X(00)00428-5