4-(2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

Base Information

• Chemical Name: 4-(2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile
• CAS No.: 914494-96-5
• Molecular Formula: C₂₃H₁₈N₆O
• Molecular Weight: 394.436

Synonyms:4-(2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

Chemical Property of 4-(2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

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Technology Process of 4-(2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

There total 1 articles about 4-(2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidine (129872-81-7) → 4-(2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile (914494-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / 1-methyl-2-pyrridone / 0.5 h / 20 °C

1.2: 16 h / 160 °C

2.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 48 h / 90 °C

With sodium hydride; trifluoroacetic acid; In 1-methyl-2-pyrridone; 2,2,2-trifluoroethanol;

Reference yield: 57.0%

4-(2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile (914494-96-5) → 4-(7-bromo-2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; for 16h; Heating / reflux;

Reference yield: 56.0%

4-(2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile (914494-96-5) → 4-(7-chloro-2-(4-cyanophenylamino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile

Guidance literature:

With N-chloro-succinimide; In dichloromethane; for 16h; Heating / reflux;

upstream raw materials:

2,4-dichloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidine

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