BZM₀₅₅

Base Information

• Chemical Name: BZM₀₅₅
• CAS No.: 1304017-22-8
• Molecular Formula: C₁₉H₃₂INO₂
• Molecular Weight: 433.373
• Mol file: 1304017-22-8.mol

Synonyms:BZM₀₅₅

Chemical Property of BZM₀₅₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BZM₀₅₅

There total 5 articles about BZM₀₅₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

fingolimod (162359-55-9) → BZM055 (1304017-22-8) + 2-amino-2-[2-(3-iodo-4-octylphenyl)ethyl]-1,3-propandiol (1301696-39-8)

Guidance literature:

With iodine; silver trifluoromethanesulfonate; silver sulfate; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

[1,1-bis-hydroxymethyl-3-(2-iodo-4-octyl-phenyl)-propyl]-carbamic acid tert-butyl ester (1311195-22-8) → BZM055 (1304017-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; acetone / 20 °C

2: hydrogenchloride; water / 1 h / 50 °C

With hydrogenchloride; water; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetone;

DOI:10.1002/cmdc.201000477

Reference yield:

{5-[2-(2-iodo-4-octylphenyl)ethyl]-2,2-dimethyl[1,3]dioxan-5-yl}carbamic acid tert-butyl ester (1301696-89-8) → BZM055 (1304017-22-8)

Guidance literature:

With hydrogenchloride; water; at 50 ℃; for 1h;

DOI:10.1002/cmdc.201000477

upstream raw materials:

fingolimod

[1,1-bis-hydroxymethyl-3-(2-iodo-4-octyl-phenyl)-propyl]-carbamic acid tert-butyl ester

{5-[2-(2-iodo-4-octylphenyl)ethyl]-2,2-dimethyl[1,3]dioxan-5-yl}carbamic acid tert-butyl ester

(2,2-dimethyl-5-{2-[4-octyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]ethyl}[1,3]dioxan-5-yl)carbamic acid tert-butyl ester

Downstream raw materials:

[1,1-bis-hydroxymethyl-3-(2-iodo-4-octyl-phenyl)-propyl]-carbamic acid tert-butyl ester

{5-[2-(2-iodo-4-octylphenyl)ethyl]-2,2-dimethyl[1,3]dioxan-5-yl}carbamic acid tert-butyl ester

(2,2-dimethyl-5-{2-[4-octyl-2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]ethyl}[1,3]dioxan-5-yl)carbamic acid tert-butyl ester

phosphoric acid di-tert-butyl ester (S)-4-[2-(2-iodo-4-octylphenyl)ethyl]-2-oxooxazolidin-4-ylmethyl ester