N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester

Base Information

• Chemical Name: N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester
• CAS No.: 869276-79-9
• Molecular Formula: C₉₃H₉₃N₅O₁₀
• Molecular Weight: 1440.79
• Mol file: 869276-79-9.mol

Synonyms:N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester

Chemical Property of N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester

There total 2 articles about N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester (869276-83-5) → N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester (869276-79-9)

Guidance literature:

In 1,1,2,2-tetrachloroethane; at 115 ℃; for 48h;

DOI:10.1021/ol051567t

Reference yield:

1-pyrenemethyl succinic acid monoester (869276-78-8) + {12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-carbamic acid tert-butyl ester (869276-87-9) → N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester (869276-79-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 16h; cooling;

DOI:10.1021/ol051567t

upstream raw materials:

1-pyrenemethyl succinic acid monoester

{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-carbamic acid tert-butyl ester

N-{12-[3-(2-{4-[2,9-bis-(2,6-diisopropyl-phenyl)-1,3,8,10-tetraoxo-1,2,3,8,9,10-hexahydro-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinolin-5-yloxy]-phenyl}-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid pyren-1-ylmethyl ester