(S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one

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Chemical Name:(S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one
CAS No.:648414-76-0
Molecular Formula:C₃₄H₃₃N₃O₅
Molecular Weight:563.653
Hs Code.:

Synonyms:(S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one

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Chemical Property of (S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one

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Technology Process of (S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one

There total 8 articles about (S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 288399-19-9
4-(chloromethyl)-2-methylquinoline

: 648414-75-9
(S)-4-Benzyl-3-{2-[(R)-1-(4-hydroxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one

: 648414-76-0
(S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide;
DOI:10.1016/S0960-894X(03)00313-5

Reference yield:

: 179533-67-6
(R)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)hex-5-enoate

: 648414-76-0
(S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / O₃; PPh₃ / CH₂Cl₂

2: NaBH(OAc)3 / 1,2-dichloro-ethane

3: toluene / Heating

4: 100 percent / CF₃CO₂H / CH₂Cl₂

5: 83 percent / PivCl; Et₃N; BuLi / tetrahydrofuran

6: 42 percent / KHMDS / tetrahydrofuran

7: 74 percent / H₂ / Pd(OH)2/C / methanol

8: 77 percent / Cs₂CO₃ / dimethylsulfoxide

With n-butyllithium; hydrogen; pivaloyl chloride; potassium hexamethylsilazane; sodium tris(acetoxy)borohydride; caesium carbonate; ozone; triethylamine; triphenylphosphine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
DOI:10.1016/S0960-894X(03)00313-5

Reference yield:

: 300856-46-6
[(R)-1-(4-Benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-acetic acid

: 648414-76-0
(S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / PivCl; Et₃N; BuLi / tetrahydrofuran

2: 42 percent / KHMDS / tetrahydrofuran

3: 74 percent / H₂ / Pd(OH)2/C / methanol

4: 77 percent / Cs₂CO₃ / dimethylsulfoxide

With n-butyllithium; hydrogen; pivaloyl chloride; potassium hexamethylsilazane; caesium carbonate; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/S0960-894X(03)00313-5