(7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone

Base Information

Chemical Name:(7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone
CAS No.:1300690-22-5
Molecular Formula:C₂₂H₂₀BrNO₅
Molecular Weight:458.308
Hs Code.:

Synonyms:(7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone

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Chemical Property of (7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone

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Technology Process of (7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone

There total 2 articles about (7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 79257-61-7
N-(3,5-dimethoxy-phenyl)-acetamide

: 123266-52-4
7-bromo-3-methoxy-2-naphthoic acid chloride

: 1300690-22-5
(7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone

: 1300690-23-6
(7-bromo-3-methoxynaphth-2-yl)-[2-(7-bromo-3-methoxy-2-naphthoylamino)-4,6-dimethoxyphenyl]ketone

Guidance literature:: 7-bromo-3-methoxy-2-naphthoic acid chloride; With tin(IV) chloride; In 1,2-dichloro-ethane; at 45 ℃; for 0.5h;

N-(3,5-dimethoxy-phenyl)-acetamide; In 1,2-dichloro-ethane; at 45 ℃; for 3h;
DOI:10.1016/j.ejmech.2011.02.050

Reference yield:

: 123266-62-6
7-bromo-3-methoxy-2-naphthoic acid

: 1300690-22-5
(7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 3 h / 65 °C

2.1: tin(IV) chloride / 1,2-dichloro-ethane / 0.5 h / 45 °C

2.2: 3 h / 45 °C

With thionyl chloride; tin(IV) chloride; In 1,2-dichloro-ethane; 2.1: Friedel-Crafts acylation / 2.2: Friedel-Crafts acylation;
DOI:10.1016/j.ejmech.2011.02.050

Reference yield: 92.0%

: 1300690-22-5
(7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone

: 1300690-26-9
(7-bromo-3-methoxynaphth-2-yl)-(2-amino-4,6-dimethoxyphenyl)ketone

Guidance literature:: (7-bromo-3-methoxynaphth-2-yl)-(2-acetamido-4,6-dimethoxyphenyl)ketone; With hydrogenchloride; water; In methanol; for 4h; Reflux;

With sodium hydroxide; In methanol; water; pH=10; Cooling;
DOI:10.1016/j.ejmech.2011.02.050