5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl

Base Information

Chemical Name:5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl
CAS No.:851605-37-3
Molecular Formula:C₆₉H₇₆N₂O₅
Molecular Weight:1013.37
Hs Code.:

5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl

Synonyms:5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl

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Chemical Property of 5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl

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Technology Process of 5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl

There total 9 articles about 5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 851605-35-1
5'-(3-hexyloxymethyl-5-{3-hexyloxymethyl-5-[(triisopropylsilanyl)ethynyl]phenylethynyl}phenyl)-5-{3-[3-hexyloxymethyl-5-[(triisopropylsilanyl)ethynyl]phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl

: 851605-37-3
5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1002/ejoc.200400744

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 851605-37-3
5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl

Guidance literature:: Multi-step reaction with 5 steps

1.1: nBuLi / diethyl ether; hexane / 3 h / -78 °C

1.2: 75 percent / 1,2-diiodoethane / diethyl ether; hexane / -78 - 20 °C

2.1: Bu₄NBr; Na₂CO₃; [Pd(PPh₃)4] / toluene; H₂O / 96 h / Heating

3.1: [Pd(PPh₃)4] / toluene / 120 h

4.1: 85 percent / Et₃N; [Pd(PPh₃)4]; CuI / toluene / 48 h / 80 °C

5.1: 97 percent / Bu₄NF / tetrahydrofuran / 24 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; hexane; water; toluene;
DOI:10.1002/ejoc.200400744

Reference yield:

: 73290-22-9
2-bromo-5-iodo-pyridine

: 851605-37-3
5'-{3-[3-ethynyl-5-(hexyloxymethyl)phenylethynyl]-5-(hexyloxymethyl)phenyl}-5-{3-[3-ehynyl-5-(hexyloxymethyl)phenylethynyl]-5-(tetrahydropyran-2-yloxymethyl)phenyl}-2,2'-bipyridinyl

Guidance literature:: Multi-step reaction with 4 steps

1: Bu₄NBr; Na₂CO₃; [Pd(PPh₃)4] / toluene; H₂O / 96 h / Heating

2: [Pd(PPh₃)4] / toluene / 120 h

3: 85 percent / Et₃N; [Pd(PPh₃)4]; CuI / toluene / 48 h / 80 °C

4: 97 percent / Bu₄NF / tetrahydrofuran / 24 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium carbonate; triethylamine; In tetrahydrofuran; water; toluene;
DOI:10.1002/ejoc.200400744