2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide

Base Information

• Chemical Name: 2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide
• CAS No.: 437998-64-6
• Molecular Formula: C₂₃H₂₇N₃O₂
• Molecular Weight: 377.486
• Mol file: 437998-64-6.mol

Synonyms:2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide

Chemical Property of 2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide

There total 3 articles about 2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-methylphenyl)-1,2,3,6-tetrahydropyridine (59084-09-2) + 2-[(4-bromobutanoyl)amino]benzamide (437998-35-1) → 2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide (437998-64-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm0499256

Reference yield:

anthranilic acid amide (28144-70-9,88-68-6) → 2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide (437998-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.3 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 °C

2: Et₃N / dimethylformamide / 24 h / 20 °C

With pyridine; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0499256

Reference yield:

4-(4-methylphenyl)-1,2,3,6-tetrahydropyridine (59084-09-2) + 4-bromobutyroyl chloride (927-58-2) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide (437998-64-6)

Guidance literature:

Multistep reaction;

DOI:10.1021/jm0499256

upstream raw materials:

4-(4-methylphenyl)-1,2,3,6-tetrahydropyridine

4-bromobutyroyl chloride

anthranilic acid

2-[(4-bromobutanoyl)amino]benzamide