6-dichloromethyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester

Base Information

• Chemical Name: 6-dichloromethyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester
• CAS No.: 1197988-71-8
• Molecular Formula: C₁₃H₁₆Cl₂O₄
• Molecular Weight: 307.174
• Mol file: 1197988-71-8.mol

Synonyms:6-dichloromethyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester

Chemical Property of 6-dichloromethyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 6-dichloromethyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester

There total 1 articles about 6-dichloromethyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-methoxy-1,3-bis(trimethylsilyloxy)hepta-1,3-diene (1034638-22-6) + 1,1-dichloro-4,4-dimethoxy-but-3-en-2-one (1197988-66-1) → 6-dichloromethyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester (1197988-71-8)

Guidance literature:

1-methoxy-1,3-bis(trimethylsilyloxy)hepta-1,3-diene; 1,1-dichloro-4,4-dimethoxy-but-3-en-2-one; With titanium tetrachloride; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In dichloromethane; regioselective reaction;

DOI:10.1016/j.tet.2009.09.016

Reference yield: 77.0%

6-dichloromethyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester (1197988-71-8) → 6-formyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester (1197988-78-5)

Guidance literature:

6-dichloromethyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester; With methanol; sodium methylate; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In methanol; water;

DOI:10.1016/j.tet.2009.09.016

upstream raw materials:

1-methoxy-1,3-bis(trimethylsilyloxy)hepta-1,3-diene

1,1-dichloro-4,4-dimethoxy-but-3-en-2-one

Downstream raw materials:

6-formyl-2-hydroxy-4-methoxy-3-propylbenzoic acid methyl ester