4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine hydrochloride

Base Information

• Chemical Name: 4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine hydrochloride
• CAS No.: 1027094-48-9
• Molecular Formula: C₁₉H₂₀F₃NO₂S₂*ClH
• Molecular Weight: 451.961

Synonyms:4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine hydrochloride

Chemical Property of 4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine hydrochloride

Chemical Property:

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Technology Process of 4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine hydrochloride

There total 1 articles about 4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butyl 4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine-1-carboxylate (1027094-47-8) → 4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine hydrochloride (1027094-48-9)

Guidance literature:

With hydrogenchloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 78.0%

4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine hydrochloride (1027094-48-9) + succinic acid monomethylester chloride (1490-25-1) → methyl 4-oxo-4-[4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidin-1-yl]-butanoate (1027094-51-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield: 36.0%

4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine hydrochloride (1027094-48-9) + 3-Carboxybenzenesulfonyl chloride (4025-64-3) → 3-{[4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidin-1-yl]sulfonyl}-benzoic acid (1027094-49-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

tert-butyl 4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidine-1-carboxylate

Downstream raw materials:

3-{[4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidin-1-yl]sulfonyl}-benzoic acid

methyl 4-oxo-4-[4-({[5-phenylsulfonyl-2-trifluoromethyl-phenyl]thio}methyl)piperidin-1-yl]-butanoate

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