(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinic acid

Base Information

Chemical Name:(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinic acid
CAS No.:1246766-03-9
Molecular Formula:C₂₄H₂₆N₄O₃
Molecular Weight:418.495
Hs Code.:

Synonyms:(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinic acid

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Chemical Property of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinic acid

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Technology Process of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinic acid

There total 6 articles about (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1246766-02-8
(R)-ethyl 6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinate

: 1246766-03-9
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinic acid

Guidance literature:: (R)-ethyl 6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinate; With lithium hydroxide; In tetrahydrofuran; water; at 50 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; pH=4;
DOI:10.1021/jm500206r

Reference yield: 98.0%

: 1246766-03-9
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinic acid

Guidance literature:

Reference yield:

: 58584-86-4
ethyl 2,6-dichloronicotinate

: 1246766-03-9
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-ethoxynicotinic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 19 h / 0 - 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,2-dimethoxyethane / 80 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 70 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 50 °C

4.2: 20 °C / pH 4

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 3.1: |Suzuki Coupling;
DOI:10.1021/jm500206r