2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-3,4-dihydroquinazoline

Base Information

Chemical Name:2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-3,4-dihydroquinazoline
CAS No.:1257056-98-6
Molecular Formula:C₂₁H₁₈FN₃O
Molecular Weight:347.392
Hs Code.:

Synonyms:2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-3,4-dihydroquinazoline

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Chemical Property of 2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-3,4-dihydroquinazoline

Chemical Property:

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Technology Process of 2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-3,4-dihydroquinazoline

There total 8 articles about 2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-3,4-dihydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257056-97-5
4-chloro-2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-quinazoline

: 1257056-98-6
2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-3,4-dihydroquinazoline

Guidance literature:: 4-chloro-2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-quinazoline; With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1257056-98-6
2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-3,4-dihydroquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 2 h / 65 °C

1.2: 16 h / 95 °C

2.1: trichlorophosphate / 1 h / 60 °C

3.1: hydrogen; triethylamine / palladium 10% on activated carbon / methanol / 16 h / 20 °C

With hydrogen; sodium methylate; triethylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol;

Reference yield:

: 149507-26-6
3-fluoro-4-methoxy-phenylboronic acid

: 1257056-98-6
2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]-3,4-dihydroquinazoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 2 h / 95 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

3.1: 1,2-dichloro-ethane / 1 h / 20 °C

3.2: 16.5 h / 65 °C

4.1: sodium methylate / methanol / 2 h / 65 °C

4.2: 16 h / 95 °C

5.1: trichlorophosphate / 1 h / 60 °C

6.1: hydrogen; triethylamine / palladium 10% on activated carbon / methanol / 16 h / 20 °C

With hydrogen; sodium methylate; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane;