N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(benzyloxy)benzoyl)spermidine

Base Information

Chemical Name:N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(benzyloxy)benzoyl)spermidine
CAS No.:117680-06-5
Molecular Formula:C₆₀H₆₀N₄O₁₁
Molecular Weight:1013.16
Hs Code.:

N<sup>4</sup>-((p-Nitrobenzyl)succinoyl)-N<sup>1</sup>,N<sup>8</sup>-bis(2,3-bis(benzyloxy)benzoyl)spermidine

Synonyms:N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(benzyloxy)benzoyl)spermidine

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Chemical Property of N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(benzyloxy)benzoyl)spermidine

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Technology Process of N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(benzyloxy)benzoyl)spermidine

There total 7 articles about N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(benzyloxy)benzoyl)spermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 74272-81-4
2,3-bis(benzyloxy)-N-(3-(4-(2,3-bis(benzyloxy)benzamido)butylamino)propyl)benzamide

: 117679-90-0
Succinimido ester of p-nitrobenzyl succinate

: 117680-06-5
N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(benzyloxy)benzoyl)spermidine

Guidance literature:: With dmap; In tetrahydrofuran; for 16h; Ambient temperature;
DOI:10.1021/jm00122a013

Reference yield:

: 619-73-8
4-nitrobenzyl chloride

: 117680-06-5
N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(benzyloxy)benzoyl)spermidine

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / DMAP / tetrahydrofuran / 12 h / Heating

2: 93 percent / 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0-5 deg C, 3 h, 2.) room temperature, 15 h

3: 90 percent / DMAP / tetrahydrofuran / 16 h / Ambient temperature

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jm00122a013

Reference yield:

: 2411-83-8
methyl-2,3-dihydroxybenzoate

: 117680-06-5
N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(benzyloxy)benzoyl)spermidine

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / K₂CO₃, NaI / dimethylformamide / 16 h / Ambient temperature

2: 3.05 g / aq. KOH / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) N,N'-carbonyldiimidazole / 1.) CH₂Cl₂, 1 h, room temperature, 2.) CH₂Cl₂, overnight, room temperature

4: 90 percent / DMAP / tetrahydrofuran / 16 h / Ambient temperature

With dmap; potassium hydroxide; potassium carbonate; 1,1'-carbonyldiimidazole; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00122a013