2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide

Base Information

Chemical Name:2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide
CAS No.:1022954-05-7
Molecular Formula:C₂₃H₂₃ClN₆O₂
Molecular Weight:450.928
Hs Code.:

Synonyms:2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide

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Chemical Property of 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide

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Technology Process of 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide

There total 6 articles about 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 53841-98-8
1-methyl-7-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepin-2-one

: 1022954-05-7
2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide

Guidance literature:: In 2-methoxy-ethanol; at 120 ℃; for 18h;

Reference yield:

: 1022954-12-6
1-methyl-7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-2-one

: 1022954-05-7
2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 10% palladium on activated carbon; hydrazine hydrate / ethanol / 60 °C

2: ethyl methyl ether / 18 h / 120 °C

With 10% palladium on activated carbon; hydrazine hydrate; In ethanol; ethyl methyl ether;
DOI:10.1016/j.bmcl.2010.11.045

Reference yield:

: 118-48-9
isatoic anhydride

: 1022954-05-7
2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; water / 2.5 h

2: potassium carbonate / N,N-dimethyl-formamide / 20 - 75 °C

3: ethyl methyl ether / 18 h / 120 °C

With potassium carbonate; In tetrahydrofuran; ethyl methyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.11.045