(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3S)-2-trityloxymethyl-tetrahydro-pyran-3-yl ester

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Chemical Name:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3S)-2-trityloxymethyl-tetrahydro-pyran-3-yl ester
CAS No.:126840-42-4
Molecular Formula:C₃₅H₃₃F₃O₅
Molecular Weight:590.639
Hs Code.:

Synonyms:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3S)-2-trityloxymethyl-tetrahydro-pyran-3-yl ester

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Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3S)-2-trityloxymethyl-tetrahydro-pyran-3-yl ester

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Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3S)-2-trityloxymethyl-tetrahydro-pyran-3-yl ester

There total 22 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3S)-2-trityloxymethyl-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 115793-31-2
(2R,3S)-2-(trityloxymethyl)-3,4,5,6-tetrahydro-2H-pyran-3-ol

: 126840-42-4
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3S)-2-trityloxymethyl-tetrahydro-pyran-3-yl ester

Guidance literature:: dmap; In pyridine; benzene; for 28h; Ambient temperature;
DOI:10.1248/cpb.37.2391

Reference yield:

: 76-83-5
trityl chloride

: 126840-42-4
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3R)-2-trityloxymethyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / toluene / Heating

2: Et₃N / CH₂Cl₂ / Ambient temperature

3: Bu₄NF / tetrahydrofuran / Ambient temperature

4: tert-BuOK / 2-methyl-propan-2-ol / 40 °C

5: H₂ / 10percent Pd-C / ethanol / 3040 Torr

6: 4-(N,N-dimethylamino)pyridine / benzene; pyridine / Ambient temperature

With potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; dmap; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; dichloromethane; toluene; tert-butyl alcohol; benzene;
DOI:10.1248/cpb.37.2391

Reference yield:

: 76-83-5
trityl chloride

: 126840-42-4
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3S)-2-trityloxymethyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / Et₃N / toluene / 3 h / Heating

2: 39.42 g / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: Bu₄NF / tetrahydrofuran / 14 h / Ambient temperature

4: 97 percent / tert-BuOK / 2-methyl-propan-2-ol / 4 h / 40 °C

5: 91 percent / H₂ / 10percent Pd-C / ethanol / 30 h / 3040 Torr

6: 98 percent / 4-(N,N-dimethylamino)pyridine / benzene; pyridine / 28 h / Ambient temperature

With potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; dmap; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; dichloromethane; toluene; tert-butyl alcohol; benzene;
DOI:10.1248/cpb.37.2391