(E)-(2R,5R)-2-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol

Base Information

Chemical Name:(E)-(2R,5R)-2-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol
CAS No.:186448-96-4
Molecular Formula:C₂₇H₃₈O₂S₂Si
Molecular Weight:486.815
Hs Code.:

Synonyms:(E)-(2R,5R)-2-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol

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Chemical Property of (E)-(2R,5R)-2-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol

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Technology Process of (E)-(2R,5R)-2-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol

There total 7 articles about (E)-(2R,5R)-2-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 186448-94-2
2,2-Dimethyl-propionic acid (E)-(2R,5R)-2-(tert-butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-enyl ester

: 186448-96-4
(E)-(2R,5R)-2-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol

Guidance literature:: With diisobutylaluminium hydride;
DOI:10.1021/ja963066w

Reference yield:

: 157837-43-9
(R)-4-((E)-(R)-3-[1,3]Dithian-2-yl-1-methyl-but-1-enyl)-2,2-dimethyl-[1,3]dioxolane

: 186448-96-4
(E)-(2R,5R)-2-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / CSA / methanol

2: 77 percent / DMAP

3: 66 percent

4: 92 percent / DIBAL

With dmap; camphor-10-sulfonic acid; diisobutylaluminium hydride; In methanol;
DOI:10.1021/ja963066w

Reference yield:

: 157837-35-9
(R)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-[1,3]dithian-2-yl-butan-1-one

: 186448-96-4
(E)-(2R,5R)-2-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / LHDMS / hexamethylphosphoric acid triamide; dimethylsulfoxide / 0.08 h / -78 °C

2: 70 percent / diethyl ether / 0.17 h / -78 °C

3: 64 percent / CSA / methanol

4: 77 percent / DMAP

5: 66 percent

6: 92 percent / DIBAL

With dmap; camphor-10-sulfonic acid; diisobutylaluminium hydride; lithium hexamethyldisilazane; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/ja963066w