Butenafine

Base Information

• Chemical Name: Butenafine
• CAS No.: 101828-21-1
• Molecular Formula: C23H27N
• Molecular Weight: 317.47
• Hs Code.: 2921199090
• UNII: 91Y494NL0X
• DSSTox Substance ID: DTXSID7040657
• Nikkaji Number: J276.436I
• Wikipedia: Butenafine
• Wikidata: Q850729
• NCI Thesaurus Code: C72959
• RXCUI: 47461
• Pharos Ligand ID: 9MSZVW8YKMUT
• Metabolomics Workbench ID: 43323
• ChEMBL ID: CHEMBL990
• Mol file: 101828-21-1.mol

Synonyms:butenafine;butenafine HCl;butenafine hydrochloride;KP 363;KP-363;Mentax;N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine;N-4-tert-butylbenzyl-N-methyl-1-naphthalene methylamine hydrochloride

Chemical Property of Butenafine

Chemical Property:

• Melting Point: 200-202 °C
• Boiling Point: 426.094 °C at 760 mmHg
• PKA: 7.87±0.50(Predicted)
• Flash Point: 187.687 °C
• PSA: 3.24000
• Density: 1.032 g/cm³
• LogP: 5.76930
• XLogP3: 6.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 317.214349865
• Heavy Atom Count: 24
• Complexity: 374

Purity/Quality:

99%, ^*data from raw suppliers

Butenafine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)CN(C)CC2=CC=CC3=CC=CC=C32
• Recent ClinicalTrials: Evaluate the Safety & Bioequivalence of a Generic Butenafine Cream & Lotrimin Ultra? & Compare Both to a Vehicle Control in Treatment of Interdigital Tinea Pedis
• Uses: Butenafine (Mentax) is a synthetic benzylamine antifungal agent, related structurally and pharmacologically to terbinafine. It is thought to act by inhibiting the enzyme squalene 2,3-epoxidase, resulting in decreased ergosterol and corresponding increase in squalene, with subsequent cell membrane permeability alteration and cell death. It is active against dermatophytes, yeast, and Sporothrix.