Benzyl-6-O-<6-O-acetyl-2-amino-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-amino-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid-dihydrochlorid

Base Information

• Chemical Name: Benzyl-6-O-<6-O-acetyl-2-amino-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-amino-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid-dihydrochlorid
• CAS No.: 106115-93-9
• Molecular Formula: C₅₄H₅₉N₂O₁₃P*2ClH
• Molecular Weight: 1053.92
• Mol file: 106115-93-9.mol

Synonyms:Benzyl-6-O-<6-O-acetyl-2-amino-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-amino-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid-dihydrochlorid

Chemical Property of Benzyl-6-O-<6-O-acetyl-2-amino-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-amino-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid-dihydrochlorid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl-6-O-<6-O-acetyl-2-amino-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-amino-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid-dihydrochlorid

There total 7 articles about Benzyl-6-O-<6-O-acetyl-2-amino-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-amino-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid-dihydrochlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-O-Acetyl-2-azido-3,4-di-O-<α,α-D2>benzyl-2-desoxy-α-D-glucopyranosylbromid (106139-07-5) → Benzyl-6-O-<6-O-acetyl-2-amino-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-amino-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid-dihydrochlorid (106115-93-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / silver silicate, molecular sieve 4 Angstroem / CH₂Cl₂ / 2 h / -20 °C

2: 1 M NaOMe / CH₂Cl₂; methanol / 2 h

3: 70 percent / silver silicate, molecular sieve 4 Angstroem / CH₂Cl₂ / 4 h / -20 °C

4: 1.) H₂S, 2.) 0.5 N HCl / 1.) pyridine, H₂O, 6 h, 45 deg C, 2.) toluene, MeOH, 0 deg C

With hydrogenchloride; silver silicate; 4 A molecular sieve; hydrogen sulfide; sodium methylate; In methanol; dichloromethane;

Reference yield:

Benzyl-2-azido-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid (106115-82-6) → Benzyl-6-O-<6-O-acetyl-2-amino-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-amino-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid-dihydrochlorid (106115-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / silver silicate, molecular sieve 4 Angstroem / CH₂Cl₂ / 4 h / -20 °C

2: 1.) H₂S, 2.) 0.5 N HCl / 1.) pyridine, H₂O, 6 h, 45 deg C, 2.) toluene, MeOH, 0 deg C

With hydrogenchloride; silver silicate; 4 A molecular sieve; hydrogen sulfide; In dichloromethane;

Reference yield:

Benzyl-6-O-acetyl-2-azido-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid (106115-81-5) → Benzyl-6-O-<6-O-acetyl-2-amino-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-amino-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid-dihydrochlorid (106115-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1 M NaOMe / CH₂Cl₂; methanol / 2 h

2: 70 percent / silver silicate, molecular sieve 4 Angstroem / CH₂Cl₂ / 4 h / -20 °C

3: 1.) H₂S, 2.) 0.5 N HCl / 1.) pyridine, H₂O, 6 h, 45 deg C, 2.) toluene, MeOH, 0 deg C

With hydrogenchloride; silver silicate; 4 A molecular sieve; hydrogen sulfide; sodium methylate; In methanol; dichloromethane;

upstream raw materials:

Benzyl-6-O-<6-O-acetyl-2-azido-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-β-D-glucopyranosyl>-2-azido-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid

6-O-Acetyl-2-azido-3,4-di-O-<α,α-D2>benzyl-2-desoxy-α-D-glucopyranosylbromid

Benzyl-2-azido-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid

Benzyl-6-O-acetyl-2-azido-3,4-di-O-<α,α-D2>benzyl-2-desoxy-β-D-glucopyranosid

Downstream raw materials:

Benzyl-6-O-<6-O-acetyl-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-2-(tetradecanoylamino)-β-D-glucopyranosyl>-3,4-di-O-<α,α-D2>benzyl-2-desoxy-2-(tetradecanoylamino)-β-D-glucopyranosid

Benzyl-6-O-<6-O-acetyl-3-O-<α,α-D2>benzyl-2-desoxy-4-O-(diphenoxyphosphoryl)-2-<(R)-3-hydroxytetradecanoylamino>-β-D-glucopyranosyl>-3,4-di-O-<α,α-D2>benzyl-2-desoxy-2-<(R)-3-hydroxytetradecanoylamino>-β-D-glucopyranosid