3-(4-chlorocarbonyl)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one

Base Information

Chemical Name:3-(4-chlorocarbonyl)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one
CAS No.:263715-96-4
Molecular Formula:C₁₉H₁₃ClN₂O₃
Molecular Weight:352.777
Hs Code.:

Synonyms:3-(4-chlorocarbonyl)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one

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Chemical Property of 3-(4-chlorocarbonyl)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one

Chemical Property:

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Technology Process of 3-(4-chlorocarbonyl)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one

There total 4 articles about 3-(4-chlorocarbonyl)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 263715-94-2
3-(4-carboxy)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one

: 263715-96-4
3-(4-chlorocarbonyl)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one

Guidance literature:: With thionyl chloride; In tetrahydrofuran; at 20 ℃; for 10h;
DOI:10.3987/COM-99-S61

Reference yield:

: 3034-86-4
4-ethynylbenzoic acid methyl ester

: 263715-96-4
3-(4-chlorocarbonyl)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / MeCO₂K; Pd(PPh₃)4 / dimethylformamide / 2 h / 120 °C

2: 57 percent / KOH / methanol; tetrahydrofuran / 5 h / 20 °C

3: SOCl₂ / tetrahydrofuran / 10 h / 20 °C

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium acetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Chlorination;
DOI:10.3987/COM-99-S61

Reference yield:

: 263715-90-8
3-chloro-7-methoxy-1-methylquinoxalin-2(1H)-one

: 263715-96-4
3-(4-chlorocarbonyl)phenylethynyl-7-methoxy-1-methylquinoxalin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / MeCO₂K; Pd(PPh₃)4 / dimethylformamide / 2 h / 120 °C

2: 57 percent / KOH / methanol; tetrahydrofuran / 5 h / 20 °C

3: SOCl₂ / tetrahydrofuran / 10 h / 20 °C

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium acetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Chlorination;
DOI:10.3987/COM-99-S61