2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide

Base Information

• Chemical Name: 2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide
• CAS No.: 808757-08-6
• Molecular Formula: C₂₆H₃₄N₂O₂
• Molecular Weight: 406.568
• Mol file: 808757-08-6.mol

Synonyms:2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide

Chemical Property of 2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide

There total 2 articles about 2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide (134002-25-8,103887-32-7) + 8,8-dimethoxyoctanal (148315-77-9) → 2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide (808757-08-6)

Guidance literature:

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide; 8,8-dimethoxyoctanal; In dichloromethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 14h;

Reference yield:

C28H40N2O3 → 2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide (808757-08-6)

Guidance literature:

C₂₈H₄₀N₂O₃; With hydrogenchloride; In water; acetonitrile; for 16h;

With ammonia; water; In acetonitrile; pH=12;

Reference yield: 75.0%

2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide (808757-08-6) + benzyl-methyl-amine (103-67-3) → 2-[(S)-1-(8-N-benzyl-N-methylaminooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide (808757-06-4)

Guidance literature:

2-[(S)-1-(8-Oxooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide; benzyl-methyl-amine; In dichloromethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 14h;

upstream raw materials:

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide

8,8-dimethoxyoctanal

Downstream raw materials:

2-[(S)-1-(8-N-benzyl-N-methylaminooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide