tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate

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Chemical Name:tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate
CAS No.:1276656-72-4
Molecular Formula:C₄₁H₅₇N₅O₆
Molecular Weight:715.933
Hs Code.:

tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate

Synonyms:tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate

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Chemical Property of tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate

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Technology Process of tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate

There total 4 articles about tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 3303-84-2
3-(tert-butyloxycarbonylamino)propionic acid

: 1276656-61-1
2-[6-(2-amino-5-tert-butylphenyl)pyridin-3-yl]-4-tert-butylaniline

: 1276656-72-4
tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm101410t

Reference yield:

: 1276656-57-5
4-tert-butyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1276656-72-4
tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; N,N-dimethyl-formamide / 18 h / 20 - 90 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm101410t

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1276656-72-4
tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-tert-butylphenyl]pyridin-3-yl}-4-tertbutylphenyl)carbamoyl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; N,N-dimethyl-formamide / 18 h / 20 - 90 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm101410t