(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinoyl chloride

Base Information

Chemical Name:(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinoyl chloride
CAS No.:1351168-77-8
Molecular Formula:C₂₂H₂₃Cl₂FN₄O₄S
Molecular Weight:529.419
Hs Code.:

Synonyms:(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinoyl chloride

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Chemical Property of (S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinoyl chloride

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Technology Process of (S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinoyl chloride

There total 8 articles about (S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1351168-76-7
(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinic acid

: 1351168-77-8
(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinoyl chloride

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 120278-07-1
benzyl 4-aminopiperidine-1-carboxylate

: 1351168-77-8
(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinoyl chloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: 4 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: sodium carbonate / dimethyl sulfoxide / 48 h / 120 °C

6.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 18 h / 2068.65 Torr

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

8.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

8.2: pH 1

9.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

With hydrogenchloride; thionyl chloride; water; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; lithium hexamethyldisilazane; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1351168-75-6
(S)-methyl 5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinate

: 1351168-77-8
(S)-5-chloro-6-(4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-yl)nicotinoyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

1.2: pH 1

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

With thionyl chloride; water; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;