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Technology Process of (E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile

(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile

Base Information
  • Chemical Name:(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile
  • CAS No.:196309-76-9
  • Molecular Formula:C13H15NO2S
  • Molecular Weight:249.3287
  • Hs Code.:29309090
  • European Community (EC) Number:810-953-1
  • DSSTox Substance ID:DTXSID101017376
  • Nikkaji Number:J870.168G,J1.519.137F
  • Wikidata:Q76304685
  • ChEMBL ID:CHEMBL270299
  • Mol file:196309-76-9.mol
(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile

Synonyms:3-((4-(1,1-dimethylethyl)phenyl)sulfonyl)-2-propenenitrile;BAY 11-7083;BAY 11-7085;BAY 117085;BAY-11-7083;BAY-117085

Suppliers and Price of (E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Chem-Impex
  • BAY11-7085,≥98%(HPLC) ≥98%(HPLC)
  • 10MG
  • $ 110.66
  • Chem-Impex
  • BAY11-7085,98%(HPLC) 98%(HPLC)
  • 100MG
  • $ 720.16
  • ChemScene
  • BAY 11-7085 99.99%
  • 10mg
  • $ 70.00
  • ChemScene
  • BAY 11-7085 99.99%
  • 50mg
  • $ 150.00
  • ChemScene
  • BAY 11-7085 99.99%
  • 100mg
  • $ 250.00
  • ChemScene
  • BAY 11-7085 99.99%
  • 25mg
  • $ 90.00
  • Cayman Chemical
  • BAY 11-7085 ≥98%
  • 25mg
  • $ 169.00
  • Cayman Chemical
  • BAY 11-7085 ≥98%
  • 10mg
  • $ 72.00
  • Cayman Chemical
  • BAY 11-7085 ≥98%
  • 5mg
  • $ 45.00
  • Cayman Chemical
  • BAY 11-7085 ≥98%
  • 50mg
  • $ 315.00
Total 27 raw suppliers
Chemical Property of (E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile
Chemical Property:
  • Appearance/Colour:white solid 
  • Vapor Pressure:7.73E-07mmHg at 25°C 
  • Melting Point:80-82℃ 
  • Refractive Index:1.534 
  • Boiling Point:407.1 °C at 760 mmHg 
  • Flash Point:200 °C 
  • PSA：66.31000 
  • Density:1.144 g/cm3 
  • LogP:3.87588 
  • Storage Temp.:Store at +4°C 
  • Sensitive.:Light Sensitive 
  • Solubility.:DMSO: >25 mg/mL, soluble 
  • XLogP3:2.7
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:3
  • Exact Mass:249.08234989
  • Heavy Atom Count:17
  • Complexity:420
Purity/Quality:

99%, *data from raw suppliers

BAY11-7085,≥98%(HPLC) ≥98%(HPLC) *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N
  • Isomeric SMILES:CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)/C=C/C#N
  • Uses In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling. Bay 11-7085 has been used as: nuclear factor-κB inhibitor in Panc-1 cells, macrophages inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs phospho-p65 inhibitor human monocyte cell line THP-1
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