(4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)(phenyl)methanone

Base Information

• Chemical Name: (4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)(phenyl)methanone
• CAS No.: 1432597-02-8
• Molecular Formula: C₂₆H₂₂N₄O₃
• Molecular Weight: 438.486
• Mol file: 1432597-02-8.mol

Synonyms:(4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)(phenyl)methanone

Chemical Property of (4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)(phenyl)methanone

There total 11 articles about (4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.7%

2-propyl-5-nitrobenzoimidazole (5805-43-6) + (4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone (1241048-04-3) → (4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)(phenyl)methanone (1432597-02-8)

Guidance literature:

2-propyl-5-nitrobenzoimidazole; With potassium carbonate; In acetone; at 50 ℃; for 0.5h;

(4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone; In acetone; for 6h; Reflux;

DOI:10.1055/s-0032-1329952

Reference yield:

2-propyl-5-nitrobenzoimidazole (5805-43-6) + (4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone (1241048-04-3) → (4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)(phenyl)methanone (1432597-02-8) + C26H22N4O3

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 6h;

DOI:10.1016/j.bmc.2014.02.008

Reference yield:

(4-methyl-1H-indol-1-yl)(phenyl)methanone (30933-68-7) → (4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)(phenyl)methanone (1432597-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

2.1: potassium carbonate / acetone / 0.5 h / 50 °C

2.2: 6 h / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; acetone;

DOI:10.1055/s-0032-1329952

upstream raw materials:

4-methyl-1H-indole

benzoyl chloride

(4-methyl-1H-indol-1-yl)(phenyl)methanone

4-Nitrophenylene-1,2-diamine

Downstream raw materials:

2-(4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)benzonitrile

2-(4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl)benzoic acid