N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide

Base Information

Chemical Name:N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide
CAS No.:1271524-44-7
Molecular Formula:C₂₅H₂₀Cl₂FN₃O₄
Molecular Weight:516.356
Hs Code.:

Synonyms:N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide

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Chemical Property of N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide

Chemical Property:

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Technology Process of N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide

There total 9 articles about N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1096810-19-3
5-fluoro-2-(2-methoxyethoxy)benzoic acid

: 1271523-29-5
3-amino-5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one

: 1271524-44-7
N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; for 18h;

Reference yield:

: 16512-74-6
1-(4-methoxybenzyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

: 1271524-44-7
N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / Reflux

2.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / Reflux

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.75 h / -78 °C / Inert atmosphere

3.3: -78 - 20 °C / Inert atmosphere

4.1: hydrogen / platinum(IV) oxide / 1,4-dioxane

5.1: potassium carbonate; silver carbonate / tetrahydrofuran / 1 h / Reflux

6.1: trifluoroacetic acid / dichloromethane / 3 h

7.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 18 h

With potassium tert-butylate; hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N,N-dimethyl-aniline; triethylamine; silver carbonate; trifluoroacetic acid; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1-(4-methoxybenzyl)-3,4-dihydro-1H-benzo[e] [1,4]diazepine-2,5-dione

: 1271524-44-7
N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.75 h / -78 °C / Inert atmosphere

2.3: -78 - 20 °C / Inert atmosphere

3.1: hydrogen / platinum(IV) oxide / 1,4-dioxane

4.1: potassium carbonate; silver carbonate / tetrahydrofuran / 1 h / Reflux

5.1: trifluoroacetic acid / dichloromethane / 3 h

6.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 18 h

With potassium tert-butylate; hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N,N-dimethyl-aniline; triethylamine; silver carbonate; trifluoroacetic acid; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;